GSE268210
GSE268210 is the GEO accession reported by Gu et al. 2024 for PBMC single-cell data from non-diabetes and T2D participants.
Contents
- The accession corresponds to raw files for the Gu et al. study.
- The study includes scRNA-seq from PBMCs plus V(D)J data used for TCR and BCR repertoire analysis.
- The published analysis includes 34 non-diabetes and 37 T2D participants and 293,923 analyzed PBMCs after filtering.
- Li et al. 2025 reused the 37 T2D patient PBMC scRNA-seq samples from GSE268210 and combined them with 11 healthy-control samples from GSE244515.
- In Li et al. 2025, GSE268210 contributed the T2D cases used for T-cell metabolic subtype analysis, CellChat communication analysis, transcription-factor activity inference, machine-learning subtype classification, and drug enrichment.
Relevance
- This dataset is relevant to single-cell PBMC profiling in type 2 diabetes.
- It may be useful for reanalysis or comparison against this project’s own PBMC immune findings if data-access and harmonization constraints are manageable.
- Because GSE268210 now anchors both Gu et al. 2024’s primary T2D PBMC study and Li et al. 2025’s immunometabolic reanalysis, it should be treated as a recurring dataset rather than an independent replication source.
- Findings from Li et al. 2025 and Gu et al. 2024 are not statistically independent when they use the same T2D samples.
Links
- pbmc-immune-changes-in-type-2-diabetes
- paper-evidence-map-t2d-pbmc-ancestry
- li-2025-immunometabolic-alterations-t2d
- gse244515
- t2d-t-cell-immunometabolic-subtypes