GSE29221

GEO accession for the skeletal muscle microarray dataset used by Tang et al. 2026 as an independent ROC validation set.

• Organism: Homo sapiens
• Tissue: Skeletal muscle biopsy
• Samples: 3 male T2DM patients, 3 male non-diabetic controls
• Platform: Microarray
• Source study: Jain et al. 2013, PLoS One — DOI

Usage in Tang et al. 2026

• Independent validation of diagnostic AUC for the four signature genes (PNLIP, BUB1, CTSB, NAMPT).
• AUCs: BUB1 = 0.931, CTSB = 0.882, PNLIP = 0.819, NAMPT = 0.694.
• Cross-tissue validation (islet-derived genes tested in muscle data) — a methodological limitation noted by the authors.

Links

• Tang et al. 2026
• GSE221156 — primary discovery dataset