GSE255566

GSE255566 is the NCBI GEO accession for the PBMC scRNA-seq dataset reported by Zhao and Fang 2025. Data are available at GSE255566.

Key Facts

• Zhao and Fang 2025 state that the sequence data were obtained from NCBI under GEO accession GSE255566. ¹
• The associated study includes 3 healthy participants and 3 T2DM patients, with PBMCs isolated from whole blood and profiled using 10x Genomics scRNA-seq. ¹
• The paper reports 13,591 retained cells after quality control and annotates four broad PBMC cell types: B cells, T cells, monocytes, and NK cells. ¹

Interpretation For This Project

• GSE255566 can serve as an external small-cohort comparator for single-cell PBMC profiling in T2D.
• The dataset should be treated as pathway-generating rather than definitive replication evidence because the source cohort is small and single-center.
• The study does not report genetic ancestry inference, so GSE255566 is not direct evidence for ancestry-associated immune differences.

Links

• Zhao et al. 2025 Single-Cell PBMCs in T2D
• PBMC Immune Changes in Type 2 Diabetes
• NF-kB and IFN-Gamma Signaling
• Paper Evidence Map: T2D PBMC Ancestry

Sources

• Zhao et al. 2025

Footnotes

1. extracted; from Zhao 2025 ↩ ↩² ↩³